Ketorolac MOA is:

Ketorolac MOA is:

• A. Inhibits only COX-2
• B. Inhibits 5-lipoxygenase
• C. Non-selective COX-1 and COX-2 inhibitor
• D. Blocks NMDA receptors

Answer: (C)

Ketorolac works by blocking the enzymes that convert arachidonic acid into prostaglandins. It inhibits both COX-1 and COX-2, making it a non-selective COX inhibitor. This reduces prostaglandin production, which lowers inflammation and pain. It does not inhibit the 5-lipoxygenase pathway, which would affect leukotriene synthesis, and it does not act on NMDA receptors. It’s also not selective for COX-2, which would spare COX-1. So the mechanism that best describes ketorolac is non-selective inhibition of both COX-1 and COX-2.

Ketorolac works by blocking the enzymes that convert arachidonic acid into prostaglandins. It inhibits both COX-1 and COX-2, making it a non-selective COX inhibitor. This reduces prostaglandin production, which lowers inflammation and pain. It does not inhibit the 5-lipoxygenase pathway, which would affect leukotriene synthesis, and it does not act on NMDA receptors. It’s also not selective for COX-2, which would spare COX-1. So the mechanism that best describes ketorolac is non-selective inhibition of both COX-1 and COX-2.