Meperidine potency equivalence to morphine?

Meperidine potency equivalence to morphine?

• A. 60 mg morphine
• B. 20 mg morphine
• C. 10 mg morphine
• D. 5 mg morphine

Answer: (C)

Meperidine is roughly one-tenth as potent as morphine. In equianalgesic dosing, you match analgesia by using about ten times as much meperidine as morphine. So, to achieve the same effect as a given amount of morphine, you’d need about ten times that dose of meperidine. A commonly used equivalence is that 100 mg of meperidine is similar in effect to about 10 mg of morphine. Therefore, the morphine dose that best reflects this equivalence is 10 mg. The other morphine doses don’t align with the 1:10 potency relationship, so they aren’t-equivalent options.

Meperidine is roughly one-tenth as potent as morphine. In equianalgesic dosing, you match analgesia by using about ten times as much meperidine as morphine. So, to achieve the same effect as a given amount of morphine, you’d need about ten times that dose of meperidine. A commonly used equivalence is that 100 mg of meperidine is similar in effect to about 10 mg of morphine. Therefore, the morphine dose that best reflects this equivalence is 10 mg. The other morphine doses don’t align with the 1:10 potency relationship, so they aren’t-equivalent options.