Meperidine releases histamine to a greater extent than morphine, which can cause which effect at high doses?

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Multiple Choice

Meperidine releases histamine to a greater extent than morphine, which can cause which effect at high doses?

Explanation:
Meperidine releases histamine from mast cells more than morphine, and histamine causes vasodilation of peripheral vessels. This vasodilation lowers systemic vascular resistance and falls in blood pressure occur, especially at higher histamine release. So the primary hemodynamic effect is hypotension. Reflex tachycardia can accompany the drop in pressure, but the direct and most notable change with high-dose histamine release is reduced blood pressure.

Meperidine releases histamine from mast cells more than morphine, and histamine causes vasodilation of peripheral vessels. This vasodilation lowers systemic vascular resistance and falls in blood pressure occur, especially at higher histamine release. So the primary hemodynamic effect is hypotension. Reflex tachycardia can accompany the drop in pressure, but the direct and most notable change with high-dose histamine release is reduced blood pressure.

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