Naloxone bolus dose commonly used is

Naloxone bolus dose commonly used is

• A. 0.04 mg
• B. 0.4 mg
• C. 4 mg
• D. 40 mg

Answer: (A)

Naloxone works by competitively blocking mu-opioid receptors, so only a tiny IV amount is needed to reverse opioid-induced respiratory depression. The common bolus is 0.04 mg (40 micrograms) because this small dose quickly restores ventilation without overshooting and precipitating withdrawal or abrupt loss of analgesia. If reversal is incomplete, doses can be titrated in small increments (often 0.04 mg every few minutes) to achieve the desired effect. Larger initial boluses (0.4 mg, 4 mg, or more) are rarely appropriate and increase risks such as sudden withdrawal, hypertension, tachycardia, and pain control disruption.

Naloxone works by competitively blocking mu-opioid receptors, so only a tiny IV amount is needed to reverse opioid-induced respiratory depression. The common bolus is 0.04 mg (40 micrograms) because this small dose quickly restores ventilation without overshooting and precipitating withdrawal or abrupt loss of analgesia. If reversal is incomplete, doses can be titrated in small increments (often 0.04 mg every few minutes) to achieve the desired effect. Larger initial boluses (0.4 mg, 4 mg, or more) are rarely appropriate and increase risks such as sudden withdrawal, hypertension, tachycardia, and pain control disruption.