Propofol maintenance infusion rate is typically:

Propofol maintenance infusion rate is typically:

• A. 5-25 mcg/kg/min
• B. 25-50 mcg/kg/min
• C. 25-200 mcg/kg/min
• D. 200-300 mcg/kg/min

Answer: (C)

Propofol is a short-acting hypnotic given as a continuous infusion, and the rate is adjusted to maintain the desired depth of anesthesia while keeping hemodynamics acceptable. In adults, the maintenance infusion typically ranges from about 25 to 200 mcg/kg/min. The lower end can be sufficient for lighter anesthesia or in patients who are more sensitive, while higher rates are used to deepen anesthesia or when a quicker onset of deeper hypnosis is needed. Rates above 200 mcg/kg/min are uncommon and can markedly depress respiration and blood pressure, so they’re not part of the routine maintenance range. For context, 25 mcg/kg/min equals roughly 1.5 mg/kg/hr, and 200 mcg/kg/min equals about 12 mg/kg/hr, illustrating how the rate spans a wide, titratable range to match clinical needs.

Propofol is a short-acting hypnotic given as a continuous infusion, and the rate is adjusted to maintain the desired depth of anesthesia while keeping hemodynamics acceptable. In adults, the maintenance infusion typically ranges from about 25 to 200 mcg/kg/min. The lower end can be sufficient for lighter anesthesia or in patients who are more sensitive, while higher rates are used to deepen anesthesia or when a quicker onset of deeper hypnosis is needed. Rates above 200 mcg/kg/min are uncommon and can markedly depress respiration and blood pressure, so they’re not part of the routine maintenance range. For context, 25 mcg/kg/min equals roughly 1.5 mg/kg/hr, and 200 mcg/kg/min equals about 12 mg/kg/hr, illustrating how the rate spans a wide, titratable range to match clinical needs.