Remifentanil induction dose is in the range of:

Remifentanil induction dose is in the range of:

• A. 2-5 mcg/kg
• B. 0.2-0.5 mcg/kg
• C. 10-20 mcg/kg
• D. 0.01-0.05 mcg/kg

Answer: (A)

Remifentanil is an ultra-short-acting opioid, so it acts quickly and clears rapidly once given. For induction, you want a bolus that delivers fast analgesia and effectively blunts the hemodynamic response to laryngoscopy and tracheal intubation, but you don’t want it to linger and depress respiration or delay recovery. Because of its rapid metabolism by plasma esterases, a moderate bolus is used—large enough to produce a prompt effect, yet not so large that it causes prolonged apnea or chest wall rigidity. Small doses may fail to blunt the pressor response, while overly large doses raise the risk of respiratory depression and instability. This is why the induction dose is chosen in the mid-range for bolus opioids used during anesthesia.

Remifentanil is an ultra-short-acting opioid, so it acts quickly and clears rapidly once given. For induction, you want a bolus that delivers fast analgesia and effectively blunts the hemodynamic response to laryngoscopy and tracheal intubation, but you don’t want it to linger and depress respiration or delay recovery. Because of its rapid metabolism by plasma esterases, a moderate bolus is used—large enough to produce a prompt effect, yet not so large that it causes prolonged apnea or chest wall rigidity. Small doses may fail to blunt the pressor response, while overly large doses raise the risk of respiratory depression and instability. This is why the induction dose is chosen in the mid-range for bolus opioids used during anesthesia.