What is the respiratory effect of midazolam at induction dose?

What is the respiratory effect of midazolam at induction dose?

• A. It causes respiratory depression
• B. It has no effect on respiration
• C. It causes tachypnea
• D. It improves oxygenation

Answer: (A)

Midazolam is a benzodiazepine that enhances GABAergic inhibition, producing sedation and amnesia. At induction doses it can depress respiration in a dose-dependent fashion. It lowers tidal volume and blunts the respiratory response to CO2, and when given rapidly or with other depressants (opioids, propofol, volatile agents) can cause hypoventilation or apnea. It also reduces upper airway muscle tone, increasing the risk of airway obstruction. So, it can cause respiratory depression rather than having no effect, causing tachypnea, or improving oxygenation.

Midazolam is a benzodiazepine that enhances GABAergic inhibition, producing sedation and amnesia. At induction doses it can depress respiration in a dose-dependent fashion. It lowers tidal volume and blunts the respiratory response to CO2, and when given rapidly or with other depressants (opioids, propofol, volatile agents) can cause hypoventilation or apnea. It also reduces upper airway muscle tone, increasing the risk of airway obstruction. So, it can cause respiratory depression rather than having no effect, causing tachypnea, or improving oxygenation.